E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Belongs to the RNF168 family.

474 amino acids

MPPVSEVDRGPVEESSGGLKRSDCVCPVCLEIFLEPVTLPCMHTFCKPCFLETVDKSNMCCPLCRKRVSTWARLNSRNKTLVNMELWRRIQDAFPSQCERRVQGIDDDEEAVMIPKPRVCQPGELRKEYEDQISKLVEEKRALEEAERRASEEYIQRLLAEEEERLEEERRRREEQQLENDEKLARLLSLELNSGPASESTCNIKPAEATPAKKKPSVGDIEKFLRPVPHRQPSSSDSSPDSSLMANKENILSPPKPLSALSAEDCGKLTVHMLECNGKPSTSSFNPSTSEHTFVFNTPKSSSVKRKSSEIELQSEVDLHSKRPCALLRFDSSSEDSPFLSEVAVHEEALRSRWQQEEEDRRLALRIQKELDRENSVDRRKGSADSYQLRQKNTSVSTTTSPDVEGTKKGSNTTTAKNCTGRRGEEKTEKRLSGTTPGKRPGVKTPVSSTAVSSTVKKGTKQTTLTEMFPNMGS

53.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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