Description
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation (By similarity).
Family
Belongs to the HRD1 family.
Species
Caenorhabditis briggsae
Sequence
MRVSAGLMIGGSCVATAATVLNAFVINKQFYPSIVYLSKSNASMAVLYFQGIVLVYLMFQLLKSILFGDLRAAEAEHLSERTWHAVLETCLAFTVFRDDFSAMFVMQFIGLLFIKCFHWLADDRVDMMERSPVITLRFHLRMMTVLAALGFADSYFVSSAYFSTITKGASSQIVFGFEYAILLALVLHVTIKYLLHMHDLRNPQSWDNKAVYLLYAELLINLIRCVLYGFFAVIMLRVHTFPLFSVRPFYQSVRALHKAFLDVILSRRAINAMNSQFPVVSNDELSAMDATCIICREEMTVESSPKRLPCSHVFHAHCLRSWFQRQQTCPTCRTDIWQGRNGAAGGANAGGAAENNAAGAPPAAGIPPFLPFLGHQFGFPQAAAGAQVGGAQAGGHPGPFPHQIFYAPAPANRPEFMNLAPPPMPMAGPPGMFPMMPPPPIPQPNAAPGESSNAEPPGRPNFDRFSVEELHRMEGDMRDAILARIQAMENIMVILESAQVQMVQLAAITPLRRPVPTAEASEEETATASSVPTSVPSEEPSPAPSTPETASAPRSMFRGNLFNDTQSTSTPSTSAGPQPSLTPSTSSVPSTSSVRTPEADEVRQRRLAHLNARFPPPNPEHE
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service