Protein expression services for rnf111-a | E3 ubiquitin-protein ligase arkadia-A
Description
E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development by enhancing signaling of the subset of TGF-beta factors responsible for the formation of dorso-anterior tissues of Spemann's organizer (PubMed:11298453). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP (By similarity). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
Family
Belongs to the Arkadia family.
Species
Xenopus laevis
Fragment
single
Length
923 amino acids
Sequence
VEMIASKVSNEFNHLCSDTNKQQSDLNSNGTEQDKSLVVHKKRKSQQAGTSYAQSCEVKEYQRLLRLQPKSDEDNDSSFSDCISSPSSSSHFGDSDTMTSDEDKDNPLSSVNSTPRTQSARAQKWPRPHTDSVSSLLMKRPCYQVSSLRRPLHRKRFVKNVSSQRTQKQKERIMLQRKKREVLARQKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSPGENHQDGTTLPSGGMDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGETYRSRATLGHPRSHWGQNSQSGRTQEQRTRNRVSTIIQPLRQNTTEVVDLTVDEDDPTVVPTTSGRVESQPVSIVSSLTSTSEPASDSMSGLMGSAVPEIPAIPPNTVGTIADDSRTCTSGANADGGPPAMPRLPSCCPQHSPCGGSSQNHVLGHPHSSCFPPHSHHFPHHHHHHHHSSHPGVPLSPSFRDSHCTVERNAAVPPPCGVSSSSGSTYHDPQALPVDLSNNGIRSHGSVGFHSTSAFDPCCPGSSSRSTVYGHQATTSTAQTMAIDGYGSSMVAQAQPPPPLSSCRHYMHASYTSLPRPLHHQTSSCPHSNSASQPPPPPPPPPPPPMDYVIAHQVPFISPLPSLTSTHAVPPPPPSHHLSAAAAPLPQHLSTSHQSMSHHISATAPATQRLHAHEVIQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQGPERSAWEIAIETGVTAAPYQTGPLHTHLAPYHPPPRLHHLQIGALPLMVPDMAGYPHIRYISSGLDGRSFRVPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVSTDWFSQRKLHSKQDGEEAPEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIDTQLPTES
Mass
101.3 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make rnf111-a using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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