Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation.

Belongs to the dynactin 150 kDa subunit family.

1224 amino acids

MAQSRRHPHGRASSAGPRMSTEASSKPLKVGSRVEVIGKGHRGTVAYVGATLXATGKWVGVILDEAKGKNDGTVQGRKYFTCEENHGIFVRQSQIQVFEDGADTTSPETPESAALKVPKRHSRXAAKGSKLRGAKPKKTTARRPKPTRTPTSAPSSGTAGPSGSASASGGEMSSSEPSTPAQTPLVAPVIPSPSLTSPVAPMVPSPTKEEENLRSQVRDLEEKLETLKIKRNEDKAKLKELEKYKIQLEQVQEWKSKMQEQQADLQRRLKEAKKEAKDALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVDSLKEKVEYLTMDLEILKHEIEEKGSDGAASSYQVKQLEEQNARLKEALVRMRDLSASEKQEHVKLQKQMEKKNTELESLRQQREKLQEEVKQAEKTVDELKEQVDAALGAEEMVETLTERNLDLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDLAAARVREAEKRVEAAQETVADYQQTIKKYRELTAHLQDVNRELMSQQEASAEKQQQPPPEIFDFKIKFAETKAHAKAIEMELRQMEVQQANRHVSLLTSFMPDSFLRHGGDHDCILVLLLIPRLICKADVISKQAQEKFELNENCTARAGLRGAAGEQLSFAAGLVYSLSLLQATLHKYEQALNKCSVEVYKKVGMLYPEMSVHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQAEDCTMQLADHIKFTQSALDCMGVEVCRLRAFLQAGQEASDLAILLKDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALGFGQQVSDTLLDCRKHLTWVVAVLQEVAAAGAQLIAPLAENGAAGGEAGGLGLQSQRADLQRSGHQPLRVPAPVLQHPHCHHEQDATAMQEGEYDADRPQSKPTPPAELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSASKDADDRVEKIQTKLDETQTLLKKKEKEFEETMDALQADIDQLESEKVELKQRLNNQSKRTIEGLRGAPASGVASIVSGIAGEEQQRGVGAGQAAGGSAGPVQVKDSPLLLQQIEALQLSIRHLKNENNRLKGAQMKLELAGLKPLQVAKVSLPQSKQGEGPATLTLYRKSTQLLETLYQMSTNAKVVDTKQTKSGRSGARLLEQTARLWAMKGSIEALRTRPCGRWCSSSRARASPPASACSPPRPS

135.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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