Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in P.furiosus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.

Belongs to the STT3 family.

967 amino acids

MVKTQIKEKKKDEKVTIPLPGKIKTVLAFLVVLAFAAYGFYIRHLTAGKYFSDPDTFYHFEIYKLVLKEGLPRYYPMADAPFGSLIGEPLGLYILPAIFYKIISIFGYNELEAFLLWPPFVGFLSVIGVYLLGRKVLNEWAGMWGAIILSVLTANFSRTFSGNARGDGPFMMLFTFSAVLMLYYLTEENKNKKIIWGTLFVLLAGISTAAWNGSPFGLMVLLGFASFQTIILFIFGKINELREFIKEYYPAYLGILAISYLLTIPGIGKIGGFVRFAFEVFLGLVFLAIVMLYGGKYLNYSDKKHRFAVVAVIVIAGFAGAYIYVGPKLFTLMGGAYQSTQVYETVQELAKTDWGDVKVYYGVEKPNGIVFFLGLVGAMIVTARYLYKLFKDGRRPHEELFAITFYVMSIYLLWTAARFLFLASYAIALMSGVFAGYVLETVEKMKESIPIKAALGGVIAIMLLLIPLTHGPLLAQSAKSMRTTEIETSGWEDALKWLRENTPEYSTATSWWDYGYWIESSLLGQRRASADGGHARDRDHILALFLARDGNISEVDFESWELNYFLVYLNDWAKFNAISYLGGAITRREYNGDESGRGAVTTLLPLPRYGEKYVNLYAKVIVDVSNSSVKVTVGDRECDPLMVTFTPSGKTIKGTGTCSDGNAFPYVLHLTPTIGVLAYYKVATANFIKLAFGVPASTIPGFSDKLFSNFEPVYESGNVIVYRFTPFGIYKIEENINGTWKQVYNLTPGKHELKLYISAFGRDIENATLYIYAINNEKIIEKIKIAEISHMDYLNEYPIAVNVTLPNATSYRFVLVQKGPIGVLLDAPKVNGEIRSPTNILREGESGEIELKVGVDKDYTADLYLRATFIYLVRKSGKDNEDYDAAFEPQMDVFFITKIGENIQLKEGENTVKVRAELPEGVISSYKDELQRKYGDKLIIRGIRVEPVFIAEKEYLMLEVSASAPHH

108.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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