S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

Belongs to the diphthine synthase family.

287 amino acids

MLYLVGLGLSDETDITVKGLEVVKKASRVYLEAYTSILLVEQSVLESYYGRSITVADREMVESNSEEILRNAQNEDVAFLVVGDPFGATTHTDLVLRARELEIPVRTVPNASIMSGIGACGLQLYNFGQTVSMVFFTDTWKPASFYDRIKENRQIGLHTLVLVDIKVKEQSLENMARGRLVYEPPRYMTVGQCAQQMLEIEEERKEGVYAKDSLAIGAARVGGRTEKFVAGTLEELCSTDEELGPPLHSLVLLGRRTHELELDYVRQFAVDKEKWDKIWNAEYGKQL

32.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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