Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

571 amino acids

MSYQGKKNIPRITSERLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHLQMPYRGMTTVDDFLQGTKAALAGGTTMIVDHVIPEPEASLTEAFEKWREWADGKTCCDYSLHVDITHWSDSVKQEVETLVKQKGVNSFMVYMAYKDLYQMSNTELYEIFTFLGSLGAIAQVHAENGDIIAQEQNRMLELGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVMSKSSVDLISQARKKGYVVFGEPITASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQVTGSAHATFSTAQKAIGKDNFTLIPEGTNGIEERMSVIWDKSVATGKMDENQFVSVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKSHHSAAEYNIFEGMELRGAPLVVICQGKIMMEDGTLHVTQGTGRFIHCSPFPDYVYKRIKARTKMAELHGVPRGMYDGPVYDLASTPKAGTPAGSTKGSPTKQTPPVRNLHHSAFSLAGNQGDESGVRSASRRIVAPPGGRSNITSLS

62.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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