Catalyzes the cyclization of farnesyl diphosphate to protoilludene, the first step in the biosynthesis of all melleolides. Melleolides are antimicrobial and cytotoxic natural products.

Belongs to the terpene synthase family.

346 amino acids

MSQRIFLPDTLANWQWPRHLWPHYAEVKKASAAWAKSFRAFQTKAQEAFDRCDFNLLASFAYPLADEARLRSGCDLMNLFFVIDEYSDVSTEEEVRAQKDIVMDAIRNTEKPRPAGEWIGGEVSRQFWDLAKKTASTQAQKRFIDTFDEYLESVVQQAADRNNSHVRGIESYLEVRRNTIGAKPSFALLEFDMQLPDESHQSSGYQRNLRKSCIDMLCLGNDVVSYNLEQARDDDGHNIVTIAMNELRTDVAGAMIWVDEYHKQLESRFMENFKKVPRWGGPIDLQVARYCDGLGNWVRANDQWSFESERYFGKKGPEIIQRRWITLMPKMVSEELGPQIVDGFHL

40.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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