Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using preferentially NADPH over NADH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline.

Belongs to the ornithine cyclodeaminase/mu-crystallin family.

325 amino acids

MLVISANEQRKLVNMNEVIAYAALALQEFSAERTITPIRTSLPFANEQNTALIMPSVAEGLEALGLKVVTVVPENKKIGKKTINGIVMLSDFQTGEPLALLEGSYLTMIRTGALSGVATKHLARHNAKTLCIIGTGEQAKGIAEAVFAVRDIEKVMLYNRTEEKAYAFAQYIQEKFGKPAYVYANANEAISEADIIVTTTNASTPVFSEKLQKGVHINAVGSFRPNMQELPSHAIANANKVVVESKEAALEETGDLQVPVREGLFEASDIHAELGQIISGEKAGRESDEEITVFKSVGLAVVDIIVAKYLYEKAVERGVGERIEF

35.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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