Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687). The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687). Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687). The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).

Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.

331 amino acids

MTPPLLALEEHYYSTAIFNSIGETFQRTLQGVPGLADQLRSLGDGRLEAMNRGNISLQVVSHAFTPGGPSAEACRAGNDELAAEIAQISDPQRFAAFAVLPVADPTASAAELDRSVSELGFVGALIDNHADGKHFDGHDYDVLWAKACELDVPIYLHPTWPSARMAENFMGSYPVPVGISLGGPGWGWHPDVGLHVLKLFAAGVFDRFPRLKIIVGHMGEMLPYMLERASDMSTRWGGWGPRDRPLRQVWDENIWITTSGSWSLAPLKCILHNTKVERIMYSVDYPFESNERGLEWFKELEGSGLLTEEQLEMVAYRNAEDLLKVHMKKEQ

36.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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