Hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha-ketoglutarate (alpha-KG) and cysteinylglycine (specific activity 6.50 umol/min/mg), has less activity against alpha-ketoglutaramate (a-KGM, specific activity 0.20 umol/min/mg), very little activity on glutathione and none on L-glutamine. May function as a metabolite repair enzyme.

Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

286 amino acids

MKNANVALLQLCSGENTRDNLAQIEQQIKQLNSGIQLVMTPENALLFANAASYRHHAEQHNDGPLQQEVREMARRYGVWIQVGSMPMISRESPDLITTSSLLFDSQGELKARYDKIHMFDVDIKDIHGRYRESDTYQPGEHLTVADTPVGRLGMTVCYDLRFPGLFQALRAQGAEIISVPAAFTKVTGEAHWEILLRARAIENQCVILAAAQVGRHGATRRTWGHTMAVDAWGKIIGQNPDAVSALKVKIETTGLKTIRNQMPVLQHNRFVSSLVPRLSDSKQSSK

31.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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