DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Belongs to the RNA polymerase beta chain family.

1360 amino acids

MALTFTEKKRLRKNFGRISSIIDIPNLISVQKESFVRFLQTGTEFEKMKDTGLHGVFLSVFPIHDYAGTVSLEYVSYALGEPKYDVDECLQRGMTFSAPLKVAFRLVIWDENEETGTKTVREIKEQDVYLGEIPLMTNTGTFIINGTERVIVSQMHRSPGVFFDHDRGKTHSSGKLLFSARVIPYRGSWLDFEFDPKDLLFARIDRRRKLPVTTLLRAMGMSSEQILERFYEIETFRKEGVVWQKRMVPERLMGNRLNYAIVHPESGEEIVKAKKRVTARHIKKFEELGMDWLPVSQEELIGSFVARNMSDVMGEVVIEAGAEITEEMVQYLEDGGIKEIDVLFIDGMSVGAYLRNTLALDKNSGQDEALIDIYRMMRPGEPPTVDAAKALFNNLFFNSDRYDLSTVGRLKMNSRLSLNTELHIRTLQHDDILGVVDILLKLKDGHGKVDDIDHLGNRRVRSVGELLENQVRIGLVRMERAIRERMSSAEADQLVPHDVMNSKPFSAVIREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGMTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARINEFGFIESPYRQVKEGTPIDQVDFLSAIDEENYIIAQANAKLGDEASEEDALIQCRHKLEFMVATPDRVNYQDVSPKQTVSVAASLIPFLENDDANRALMGSNMQRQAVPLIKTDAPLVGTGIESVVARDSGVTITARRTGVVDEVDAARIVVKADEEPGSTEPGVDIYNLTKFSRSNQNTCINQVPLVKNGERVTAGDIIADGPSTQIGELALGRNVLVAFMPWNGYNFEDSILISERLVAEDVFTSIHIDEFEVMARDTKLGAEEITRDMPNVGEDALRNLDESGIIYVGAEVKPGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTVVDVRVFSRRGLEKDDRAKLIDQDEIALLRKDMAAERRIIERDADERIRNLMNGKPVRSAPGLQPGDHISQSWLDKSPSSHLRDVVLDDDAITQQIEGIRHHVEKAADRLKKRFESKVEKLERGDDLPPGVLKMVKVYIAVKRKLQPGDKMAGRHGNKGVISKINPLEDMPYMANGTPVDIVLNPLGVPSRMNVGQILETHLGWAARGMGFKIEEALKQHRKGVADVLRRQFEEIYDNTRESAEIAALSDDQLVDMAKNLQYGVPTATPVFDGAIESDISSWLNKAGLPTSGQIQLIDGRTGEPFDRHVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKIYESIVKGDDTFEAGVPESFNVLVKELQALALDVTLQRDD

152 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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