Description
Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.
Family
Belongs to the SMC family. RAD50 subfamily.
Species
Caenorhabditis elegans
Sequence
MAKFLRLHIRGIRSVGDEDHDVHKIDFLSPCTLISGPNGTGKTTTIEALNFVTTGQMPTQKKQNFIHSTDVARKTRVDASVTLEFIDVKGRECTAVRRLVVTSGTKAAALAEEHTLAIKYPDGTVNTLSSKVCDFNTALLKHLGVPRAVFKYVIFCHQEDSTWPLSEPKELKKRFDDIFQLTKFVKAQERMKKIVLDFKKEMQTHEMSKQLYETHVRDKLVARQNQEECERKISKRKEETDELKERKANGQKKIEEMRTSIHELEDTLTSFKKTELERQNLKKQLSLIRVEPYFGTEEELKREIEEFRGSEGRSYGEERARIQKKIGKNNQERQELSQKKTEFENRISSLKAEVIHCQSLKYDLERLENQLRSELDLEHDADIDIEIDNAITLKIRGMSDKARMIAKNCAELQSNLRTAQEAATKIEVEMKTLQNEKVKLEKEVEQLKFKIKQGQNATAGMKDLLKKEEALRKSLADLPLLDENALTECKLKREKYLKQLDILKKKCAEAEKNAEKDREKESLKQTLSIARKKMTAYQRIYDNNWQGLIGQAPDFPWTPILSKTFHKLRNDKKIMEEDLRDVQLNVQKLETMQHQYRKQEESLTAQELKLSENIFEACSCEAEEVSEKLENLRKRLKKARKDLAPLSAKSNLYDSYIEESKSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANELQRIVKELKEVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGEELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKKELDQKIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDATSETSSKKVAYEYNVMMVHETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYIYCLGKDEHGISFLSKRYPDGTVKRVNTKRRF
Simulated SDS-PAGE
![Western blot of rad-50 recombinant protein](/recombinant/rad-50-1.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service