ATP-dependent 3'-5' DNA helicase involved in nucleotide excision repair (NER) of damaged DNA. XPB-R is a paralog of XBP, but is not a component of the TFIIH basal transcription factor and is dispensable for RNA polymerase II transcription.

Belongs to the helicase family. RAD25/XPB subfamily.

777 amino acids

MQCLFLEERIKKEGCVVLFAEAFRPSFANIQGFLTTIAEPVSRLSLMHEYRMTYFSLGAAASASISVSEVIQFLDDHVYFFRDKCFASYRESVCAFAEMYMSRCNLARVVIDESRTLLECKDIVTAKTLLKDRVVRSLCCQPKETVGEDACPHFLLKSRAAARVVAERCVLLGYPLQQQYEYEKDTSIRNVNIALKSQTRPRPYQIAAVDAAASDGALRSGCIVLPCGSGKTLVGIMLLCKVKKPTLILCAGGVSVEQWRNQILEFASVCAPANNEEGDPSNSTTGEKVRTAAVGAARISCLTGKQKDEITDETDIVLTTYSMLVTAHKAQARCQVEGFEMNADGRGRNPRRANPKERLFQPYGLLIMDEVHMMPADAYKDSLGFINAKGVVGLTATYVREDSKIRDLFHLVGPKLFDISWERLASSGYLAHVTCIEVLTPLARRFSLEYLERSSELTSPQHGTPLLVMLAAANPNKMLCVMEIVKRHVAESSKILVFCDHIMLLKEYSKLLGAPVVCGDTPHRERLMIFSDFQSTSKVNVVCLSRVGDVSVNLPSANVVVQVSSHGGSRRQEAQRLGRILRPKEKASNGKPTDAWFYTVISTDTVEMSYAAHRTAFLVDQGYTCSVTEFNPDGAPEAAVEGVDDTAPGDVVSIRQAKLRGTFKKQELKCSVASPTAQGSVNPRSLDYQEKLLCRVVASWELDYQNATSQQNEPGVANDTATGLIDKKMKRARDETAEDIKREWNSGAQTTQPRGDFCRLPLQRLVGANDDVVYHES

85.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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