Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Belongs to the DNA polymerase type-Y family.

358 amino acids

MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASGYALKLCPDLILVPGRMQVYKEVSSQIRAVFERYTYLIEPLSLDEAYLDVTDSPHCKGSATLIAEAIRADILAETGLTASAGIAPVKFLAKIASDLNKPNGQYVIRPDMINEFVKTLPLIKIPGVGKVTAKKLADLGLHTCSDVQAYPPAQLIERFGKFGTVLIERSKGVDKRGISPNRERKSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRTIHKQVVKIKFEDFKQTTIEHRSDDISVNLFYQLLEQAMERQHERGIRLLGVSVGLASNSSTTDDSDVDSSQLDLGF

39.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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