Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

Belongs to the archaeal DNA polymerase II family.

1139 amino acids

MIVMVHVACSENMKKYFENIVDEVKKIYRIAEECRKKGFDPTDEVEIPLAADMADRVEGLVGPKGVAERIRELVKELGKEPAALEIAKEIVEGKFGNFDKEKKAEQAVRTALAVLTEGIVAAPLEGIADVKIKKNPDGTEYLAIYYAGPIRSAGGTAQALSVLVGDFVRKAMGLDRYKPTEDEIERYVEEVELYQSEVGSFQYNPTADEIRTAIRNIPIEITGEATDDVEVSGHRDLPRVETNQLRGGALLVLVEGVLLKAPKILRHVDKLGIEGWDWLKDLMSKKEEKEEEKDEKVDDEEIDEEEEEISGYWRDVKIEANKKFISEVIAGRPVFAHPSKVGGFRLRYGRSRNTGFATQGFHPALMYLVDEFMAVGTQLKTERPGKATCVVPVDSIEPPIVKLKNGDVIRVDTIEKAMDVRNRVEEILFLGDVLVNYGDFLENNHPLLPSCWCEEWYEKILIANNIEYDKDFIKNPKPEEAVKFALETKTPLHPRFTYHWHDVSKEDIILLRNWLLKGKEDSLEGKKVWIVDLEIEEDKKAKRILELIGCCHLVRNKKVIIEEYYPLLYSLGFDVENKKDLVENIEKILESAKNSMHLINLLAPFEVRRNTYVYVGARMGRPEKAAPRKMKPPVNGLFPIGNAGGQVRLINKAVEENNTDDVDVSYTRCPNCGKISLYRVCPFCGTKVELDNFGRIKAPLKDYWYAALKRLGINKPGDVKCIKGMTSKQKIVEPLEKAILRAINEVYVFKDGTTRFDCTDVPVTHFKPNEINVTVEKLRELGYDKDIYGNELVDGEQVVELKPQDVIIPESCAEYFVKVANFIDDLLEKFYKVERFYNVKKKEDLIGHLVIGMAPHTSAGMVGRIIGYTKANVGYAHPYFHAAKRRNCDGDEDSFFLLLDAFLNFSKKFLPDKRGGQMDAPLVLTTILDPKEVDGEVHNMDTMWSYPLEFYEKTLEMPSPKEVKEFMETVEDRLGKPEQYEGIGYTHETSRIDLGPKVCAYKTLGSMLEKTTSQLSVAKKIRATDERDVAEKVIQSHFIPDLIGNLRAFSRQAVRCKCGAKYRRIPLKGKCPKCGSNLILTVSKGAVEKYMDVAEKMAEEYNVNDYIKQRLKIIKEGINSIFENEKSRQVKLSDFFKIG

129.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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