This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker, a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

Belongs to the DNA mismatch repair MutL/HexB family.

651 amino acids

MPKIHQLSATLSNQIAAGEVIERPASVVKELVENSIDAQATQIDVLISAAGLQEIRVSDNGIGIAPDDVATAFLRHATSKILTTRDLFNVHSLGFRGEALASIAAVADVKLTTATDSGIGTQIHVKGGEVEAQSTAAHRRGTDVEVNDLFFNTPARLKYMKSQQTELGKIVDIVSRLAMANPDIAFTVSHDGNMVVRTAGQGDLRQTLAGIYGLSVARSMVDFKAQDLDFRVSGLTSLPETTRASRNYLSLVVNGRYIKNFQLTKAVIAGYGSKLMVGRYPMGVINIEMDAALVDVNVHPTKAEVRLSKEDQLSHLLSEAIRTRLAKENLIPDALDNLPKRERYDLDQLELTLNKISPKTMPSVQPQQGQQLRENTTTNLADTAAEEPTPAPTSPDLEIGDLDDQPIFNEPQRLAAWDQRYQRLASNVVPTLVADEPEPDISHVESAERFPNLTYLAQVHGTYLLAESGDGLYILDQHAAQERVNYEYYRQAIGEVSNDQQHLLVPIVLDYSAADAISIRDHRDVLESVGLYLEDFGQNSFVVEHHPTWFKAGQEEDTIKEMVDWVLRDGRMTVAAFREKTAIMMSCKRAIKANHHLDDRQARALLQKLPECENPFNCPHGRPVLVHFSNTDLEKMFKRIQDSHESGEMQA

72.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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