Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.

Belongs to the ATP-dependent DNA ligase family.

1050 amino acids

MNTNRRSRSPDEEALEEDQHQYGAGTLSLEELDEHFPNRPRNHSKTFPFSDLFRTLFNPLIDCKPSTSGGTVRGPKPGRGGHFSKVSYHEQRRHIIERFMSRWRSEVGNDFYPAMRLILPDKDRDRGVYGLKENTIGKLLVKVMKIDRNSEDGYNLMHWKLPGGQSGVSRSVGDFAGRCLEVVSKRAMRAQPGDLTIADVNVLLDRLAAASGEAEQLPIFEEFYRQMNAEEMMWLVRIILKDMRVGATERTFLNLWHPDAEALFSVSSSLRRVCWELFDPEFRLEQQETGIKLMQCFQPQLAQFQMTTTWEKLVKNLGVTEENPEFWIEEKLDGERMQMHMIEDDTVPGGFRFAFWSRKAKDYTYLYGESLGDEQSALTRHLHKAFDDGVRNLILDGEMITWDIDIDKMVPFGTLKTAALEQQKNPSKAGPRPLYRVFDILLLNDKPLTEYTLNDRRRALERAVVGVHRRLEILPFERATSPDAIEPLLRRVVAEASEGLVLKNPRSRYSLNSRNNDWIKVKPEYMSDFGESLDCVVVGGYFGSGRRGGTLSSFLCGVRVSQNFIKSGNASAEKCLSFVKVGGGFKAEDYAEIRHHTEGKWQDWDPSSPPTEYIELGGGEKLQYEKPDVWIRPSDSVVISVKAASITQSDQFAMGWTLRFPRFRKLRLDRAWDSALDMDEFEVLRSKIKDQEQERKKMEMENRKRKPATKRARKDLVIAGMSDPSSSSAATPVIAPKETREASKRLFEGLDFCVLSDSLKPNKMTKPALEKLIKDHGGRIHQQVMDHSGQGKIIIPIADKNVIKVASLRKANPEMDIIRPKWIFDCLVQPMPFTKQKENKKGYLLPFEPTHLFHSGSEETSEEAEQAVDKFGDSYAGDLADINELKAIMEGMESDDYVSDSDWDSDSGRGRGGGDGFDMNHFLDHLEEQGTSLDDLRSFMFRRCRVFFALPSAGNGDGAAESKALRLKNYIRFGNGKVVDELETATHVVVVTAPLGESSKKEEREIAAELRYKISLREMGSPMPRIVKGEWVEDSWKEGTVVDEEEYVAG

119.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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