ATP-dependent RNA helicase that associates with the RNA exosome complex, with the cap binding complex (CBC) and with the NEXT-like complex. Involved in the degradation of a large number of non-coding nuclear exosome substrates such as snoRNA and miRNA precursors, incompletely spliced mRNAs, and spurious transcripts produced from pseudogenes and intergenic regions (PubMed:25144737). Involved in the maintenance of homeotic B and C gene expression in the reproductive whorls. Regulates floral organ spacing and identity, probably through the regulation of protein synthesis or mRNA degradation (PubMed:11923195).

Belongs to the DExH box helicase family. SKI2 subfamily.

995 amino acids

MSAQMEEPETLGKRKESESSKLRSDETPTPEPRTKRRSLKRACVHEVAVPNDYTPTKEETIHGTLDNPVFNGDMAKTYPFKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEFKDVGLMTGDVTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMSNATEFAEWICYLHKQPCHVVYTDFRPTPLQHYAFPMGGGGLYLVVDDNEQFREDSFVKMQDTFPKPKSNDGKKSANGKSGGRGAKGGGGPGDSDVYKIVKMIMERKFEPVIIFSFSRRECEQHALSMSKLDFNTDEEKEVVEQVFNNAMQCLNEEDRSLPAIELMLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQMSGRAGRRGKDERGICIIMIDEQMEMNTLRDMMLGKPAPLLSTFRLSYYTILNLLSRAEGQFTAEHVIRHSFHQFQHEKALPDIGNKVSKLEEEAAILNASGEAEVAEYHNLQFDIAKHEKKLMSEIIRPERVLCFLDTGRLVKIREGGTDWGWGVVVNVVKNSSVGTGSASSHGGGYIVDTLLHCSTGFSENGAKPKPCPPRAGEKGEMHVVPVQLPLISALSRLRISVPSDLRPVEARQSILLALQELSSRFPLGFPKLHPVKDMNIQDTEIVDLVSQIEEVEQKLLAHPMHKSEDDQQIKSFQRKAEVNYEIQQLKSKMRDSQLQKFRDELKNRSRVLKKLGHIDADGVVQVKGRAACLIDTGDELLVTELMFNGTFNDLDHHQVAALASCFIPVDKSNEQVNLRNELTKPLQQLQDSARKIAEIQHECKLEIDVEEYVESTIRPFLMDVIYSWSKGASFAEIIQMTDIFEGSIIRSARRLDEFLNQLRAAAEAVGESSLESKFAAASESLRRGIMFANSLYL

111.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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