Guanine nucleotide exchange factor (GEF) which may activate the small GTPases Rab. May promote the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).

Belongs to the RAB6IP1 family.

1311 amino acids

MSATMSGSGSAPCRFAHYFIVCGLDDETGLEPDALAALYQWLEADRQGKDPEATAAGENFDQSPLKRTFKSKVLAHYPENIECNPFDQDAVNMLCMPKGLSFRTQRDSLAPHFHSFLITREDGSRTYGFVHTFYEEVTSPQICSAMQTLHQMHQAEHNTSAQNCTSSSSSSSSSSSSSSMDSLSSSLDDVDSPSAHGGRRTCEGYDSIRDTLYVSKAMCLIAPMPFMHACKRFLAQMHRAVSCSPPPPLPLESYIYNVLYEVPLPASGRSLKFHGVYEPILCQRPGVGELPLADFPLADAFRLLGVENLVQLFTCVLLEMQILLYSQDYQRLMVVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHCIELPEDFPQFPNRSEFIQELSEVLLSFGQSPEGGSSSPEPAVMSLQTSVLEKELKSTSLRELVDDKTNGNLGGEALDVLELLQGNPTLERLQALAKRTGVKVARLEALAAGQKGDEGVGGRSPVEEEELRNAKLNVQLREVFAARFATMFADYESFVIQNSPDLESWLTNREQMHNFDKASFLSDQPEPYLPFLSHFIETQMFATFIDNKIMSQWEEKEPLLRVFDGRIEKARLYNVRAPSLRSSVYQKCTFLKESAQAIEQRLRKIDHTAIHPHLLDMKIGQGKYQQGFFPKLQADVLASGPTSNKWSNRTCSTQRRVERHRQQNEHLVLDNELKEKYMQEARNLGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKECKMKTKRMLVEKMGREAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQAREEKNEQQLESPVSNGQERRKTESSVGLPGLRVSVIQDMRHIQNMAEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAFLRCEEEKEQFLFHLLSLNAVDYFCFTSVFTTIMIPYRAVIIPIKKLSNAMTTSNPWLCVSGELGDSGILQITKNILEMTFDCQNLGKLTTVQLGHDNSGLLAKWLVDCVMVRNEITGHTYKFPCGRWLGKGVDDGSLERVLIGEFVVPCGDDEGGRGSKTPPLQRSPSQIRRISITSLTGKGNKPTTVQIQESIGEAVNNIIKHFHKPEKERGSLTVLLCGEGGLVWALEQFFHHGFRSARIFQKNVFVWDFFERIVAFMENRDQTGDLQESPEPLSLNSESLCRYVNAINNMPRNIGKDGKFQLLVCLGARDRLLPQWLPLLAESPVITRMYEENALLRDKLTVSSLLGVLETLHDFPITLETSLTKSVEL

147.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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