Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (By similarity).

1000 amino acids

MLEARVDMLSSNMIISGPAADLGAKEASRPWKKQLNSVPNSGPSARARAQPQPLSIKDKISKWEGKKEPPASDPARQTDGQEDHLPSCKVERRGSELTRTKNGMRLETERLQNDSRARTVCQDTEQLPGPRPIDGQPELSQHRGRELKPSDLRFQSDHLSVLRQVKRLEKALKDGSAGLDPQMPGTCYSPHCLPDKTEEDLPSLESHEKGGVLAAGRRAHHLEVREPGPEISEDWKGQESVYRGSRWYPPKPFINPVPKPRRTFKHAGEGDKDVSPGISFKKEKRNLPPLPSLPPPPPPLPSSPPPTSVNRRLWTGRQRPSADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVLTFPASPTSSIPDTSTKQSLSKSAFFRQNSERRNLKLLDTRKLSRDGAGSPLRTSPPSTPSSPDDTFFNLGDLQNGRKKKKIPRLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYSSLDRDLIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLEKSFKFMREAEDQLKAIPQFCFPDAKDWAPVQEFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIIVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVSVFASLLLERRVIFIADKLSTLSKCCHAMVALIYPFSWQHTYIPVLPPAMIDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLINDRFLRQMEDEDSILPRKLQVALEHILEQRNDLACDQDGGPLDCVHGPESSSLSEVVSEAFVRFFVEIVGHYPLFLTSGEERSLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK

113.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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