Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.

358 amino acids

MSYTAPTDPVNKQEVVKLSQLCELCHGRKAVLRRPKNLQKICKECFYYVFETEIHNTIVSNNLFQRGEKVAIGASGGKDSTVLAHILKLLNDRHDYGVKLVLLSIDEGIVGYRDDSLATVKRNQKQYQLPLEIVSFRDLYDWTMDEIVAIAGIRNSCTYCGVFRRQALDRGAAKLDINHVVTGHNADDMAETVLMNILRGDVARLERSTAIITQSAGSPIRRSKPFKYCYQKEIVLYAHYKKLDYFSTECTYAPEAFRGTARELMKNLEAVRPSCIIDIIQSGENLVLKKKKRHPNSKVEFKDGNRCERCGYLSSNKICKACMLLQGLEKNRASMSIDNDTNVDGAARVMRTLEKLSF

40.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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