Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Belongs to the heme-copper respiratory oxidase family.

513 amino acids

MMRKWLYSTNHKDIGTLYFMFGIWAGMVGTSLSLLIRAELGNPGSLIGDDQIYNTIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSIMLLISSSIVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSILGAVNFITTIINMRPNNMSLDQMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGCLGMIYAMMAIGLLGFVVWAHHMFTVGMDIDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQINYSPSMLWSLGFVFLFTVGGLTGVILANSSIDVTLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWYPLFTGLALNPYLLKIQFFTMFIGVNLTFFPQHFLGLAGMPRRYSDYPDTYTSWNIISSLGSYISLVATMLMLMIIWESLINKRIILFPLNMNSSIEWYQNLPPAEHSYNELPILSNF

57 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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