Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. May monitor cellular heme or NO levels.

Belongs to the GdpP/PdeA phosphodiesterase family.

658 amino acids

MSHFYERKTYRYPSYALAALAVLMAVSLFYFQWMLGLVGLLGVGFLLYYVIWSQRSLHKELQQYISNLSYRVKKVSEEALMQMPIGILLLDEEDKIEWSNRFLAACFKEQTLIGRSLAELSEPLAAFVKKGKTDEEIIELNGKQLKVIVHRHERLLYFFDVTEHMELRRRYEIERLVLAIIFLDNYDEITQGMDDQAKSQMNSLVTSVLNRWANDYGIFLKRTSSDRFIAVLNEHILTQLEKSKFSILDEVREQTAKHQAQITLSIGIGAGVSSLPELGTLAQSSLDLALGRGGDQVAIKQGNGKVKFYGGKTNPMEKRTRVRARVISHALRELIAESDKVLIMGHKYPDMDALGAAIGILKVVQSNQKEGFLVVDAMKTDAGAQRLLEEMKKQADLWARCIKPEQALELITEDTLLIVVDTHRPSLVIEERLLYRADHIVVIDHHRRGEEFIEAPILVYMEPYASSTSELVTELLEYQPKRVKLSMLEATALLAGIVVDTKSFTLRTGSRTFDAASYLRAQGADTVLVQKLLRESVANYVKRAKLIERAAIDEHGIAIAKGDENEVHDQVLIAQTADTLLTLSGVVASFVISKRGDGTVGISARSLGDVNVQVIMERLGGGGHLTNAAAQLSDVTVGEAEQQLREAIHDYFEGGKPV

73.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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