Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains (PubMed:19901023, PubMed:21257773). Also has ATPase activity, probably via the GGDEF domain (PubMed:19901023, PubMed:21257773). Overexpression leads to increased sensitivity to methyl methanesulfonate (MMS) and H(2)O(2) (PubMed:25616256). Overexpression leads to extreme sensitivity to the beta-lactam antibiotic cefuroxime (CEF), probably dependent on PDE activity (PubMed:22211522). May monitor cellular heme or NO levels (PubMed:21257773). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).

Belongs to the GdpP/PdeA phosphodiesterase family.

659 amino acids

MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLAVILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPFLSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDVTEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIFLKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKELGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIVTESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKKYEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEEFIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTGSRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEEEYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGGHLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR

74.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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