Required for deacetylation in the mating-type region and the centromere. Acts upstream of the histone deacetylases to promote transcriptional silencing. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).

537 amino acids

MPAITCVWSDGRSDTWPNVNGHSRTRSVPSLKPLPHQDSKNLLYRQICGRLLAQHVFGGAGSTQPILNQLCKRLSTGNPNNTNASTVVTAPEKNVVSARHVRPNPKSSKDTLEKQPKYSSQIYLTDSFENYYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLCSGNMTRVRKNLQKENERMFHECKDDTYTWPSSYRLGEVVWIDINNELIPAIIVARNLINYESNQMDAVKLISDTFVEPYQYHCKQLGNSRYYFDMAAADIEPWSRHPLDLQKQEHLVAHSICQTWNLFGIFQPLEGIDMEEPKFHDENYSIPLTVLPTFGGESNSLDDHFYGIFRGAEKLWINDLCVISTSSLPSVLQKTSFMYISDIYVNEDDIVCFQGSLWTQIDKNALDYNDSADNIDEHKDDLKELPRRLQMVSKLSNTYFRCLHDKSVEYVCPFADVLGRWYEPWFVKGDLNYTSEVKERTSSRLSAVGSENWVDDDFYEYLLSEIDMVSAVVM

62 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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