Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May participate in mRNA transport in the cytoplasm (By similarity).

Belongs to the constitutive coactivator of PPAR-gamma family.

1114 amino acids

MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPHTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMAFHPPHYLARPNPFGMPGIVPPYVPPQMLNIPQTSLQAKPVAPQVPSPGAPGQGPHPYNLAEPALTLETSGKNLTEQNYSNIPHEGKHTPLYERSSPINPAPSGSPNHVDSAYFPGSSTSSSSDNDEGSGGAANHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGNQIGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEASKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPASVPTHLTVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPVPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQAEQAAKVEKMRQSILEGLNFSRQSHPLPFPPPAALPFYPTSVYPRHFGPVPPAQGRGRGFAGVCGFGSPYGETVATGAYRAFRVATATGHCGAFSGSDSSRTSKSQGGIQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQGAIQGKPPYAASAEEVAKELKSRSGESKSSAMSSDGSLAENGVVAEEKPAPQMNGSAGDTRAPSHSESALNNDSKTCNTNPHLNALSTDSGCRRADALEAAVLKKEE

121.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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