Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

Belongs to the DnaA family.

456 amino acids

MSQEIWADVLGYVRKNISEVEYHTWFAPLKNLGVQDGSLVLGVRNSFAQEWLRKQYQGLLEDALRSLGAQHPQVSFQVLPASQDALLLPSDPPPAPISPGRAPAPPPADNRKTLNPKYTFENFVVGPNNNLAHAAALAVAESPGKAYNPLFIYGDVGLGKTHLMHAVGHYIAERFPEKRIEYVSTETFTNELINAIREDKTTQFRNRYRSVDLLLVDDIQFLAGKERTQEEFFHTFNALYENHKQIILSSDRPPKDIQTLEGRLRSRFEWGLITDIQSPEFETRVAILKMNAEHNRIDIPQEVLELIARQVTTNIRELEGALMRVVAFSSLNNVPFSRAVASKALSNVFAPQEVKVEMMDVLRQVASHFNMPPDVIRGSGRVREVVVPRQVAQYLIRDLTDHSLPEIGQFFGRDHSTVMHAISKVTEQLGKDSELTAAVETLRRKMKGLEDEDSRA

51.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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