Description
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). Has a key role in chorion gene regulation and nucleosome positioning. Its binding to middle chorion gene promoters is correlated with H3K4 methylation and TFIID recruitment.
Family
Belongs to the SNF2/RAD54 helicase family.
Sequence
MRRGKKGVTGNVTTIYYIEEHGDPNEGCDPNDEDSTEPQYLIKWKGWSHIHNTWESEKTINDQKVKGLKKLENFIKKEVEISWWRQQAGPEDIDYYECQSELQQELVKTYNNVERIIAEQNRELEGGGTAHEYFCKWESLPYADATWEDAVLIEKRWPVEVEHFKSREAAKSTPSRHCPVLKRRPKFHQIKEQPEYVGKDSSYHLRDYQMDGLNWLIHSWCKDNSVILADEMGLGKTIQTICFLYYLFKSQHLYGPFLCVVPLSTMTAWQREFQQWAPDINVVTYIGDVSSRDIIRQFEWSFSSSKRLKFNAILTTYEILLKDRQFLRSFSWACLLVDEAHRLKNDDSLLYKALKEFDTNHRLLVTGTPLQNSLKELWALLHFIMPYKFESWEDFEKDHEDAATKGYEKLHKQLEPFILRRQKKDVEKSLPAKVEQILRVEMTSIQKQYYKWILTKNYSALRKGVKGSINTFINIVIELKKCCNHALLTKPEDFESRASLATSDAVEKLLRGSGKLLLLDKLLCRLKETGHRVLIFSQMVRMLDILAEYLQRRHFPFQRLDGSIKGELRKQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEDIVERAKRKMVLDHLVIQRMDTTGKTVLNKRDASGTTANNPFNKEDLNAILKFGAEELFKDDEENDEDPVCDIDEILQRAETRDEGPAMVGDELLSAFKVASFTFDEEKAVNELKKDNADEEPKDWDDIIPENVRKTIAEAEKLKEMEDIYLPPRRKNQLQNNADGGRRRRGRSGDGGDGDGVDGDGEAESDASDGEASADDDRPRKRGRPPASHREKIKGFTDQEIRRFVKSYKKFSAPLKHLDSIACDAELQEKPLAELKRLGEILQERCKAVLSETAEPSEQNEGRKNNRKTFKLGGVPVNAKTLAACQDELAALDDFLPQTKEERLKWQLDFRTRPANFDVEWNVSDDSKLLAGIYQYGLGSWEAIKMDSSFEIGDKILTNEDKKPQAKHLQSRAEYLLKLIKKLLDQKNGKQKMKKPRPKRANKEPVTKDIVEDDGSSAEDKKTKGVKNDKTEKGKLKIEEVSTHDETSNDKKEKDKKRKKDEDRKGDKSKGRKKPRQRGNEGIPGPMHFTANNEPRALEVLGDLDPSVFEECKEKMRPVKKALKALDNPDQSLSETEQVSRTRACLTQIGTQIDLCVEAYPDSQKVEWRSNLWYFVSKFTNFDAKQLYKLYKYGLKKNEASKQKDGKHKENVKTNNRNNHNSINHLKSFKKNSNSKQKSDTNDKKEKKMKLEKEKTDKHDKNQHTSGVKRKLEDGECDPEPNDNKRHERYVVD
Simulated SDS-PAGE
![Western blot of CHD1 recombinant protein](/recombinant/CHD1-6.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service