Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity. Essential factor in determining the success of fungal infection by regulating survival of yeast cells during the initial colonization of the host lung.

Belongs to the glycosyltransferase 2 family.

450 amino acids

MSDSGTLSLIGGIVFLVLWVVVWSICLLGWRTARIRYAHPNIPSRLSKLPVSSAPGVTIIRPLCGLDQNLYNTLESVMKLDYPKFEVIFAVQDEKDEALPVVNMVMEKYPEVEAKVIIDSRKVGVNPKVNNLMTPFQEAKYDLLWILDSTCSVLPGTLGRSVEAFFSNTSSTASPYDPESSPLLSISDDVRKPPIAGEVGLVHQVPIAVCYQKTWGSLIEQAYLNTTHAKMYLAINATSIDSCVVGKSCMYSRDNISHLTTPSPSLRSLPDPPSGLAGFGPFLAEDNMIGLSLWHELKLKHAMTSDVVLDFIGSLSVRDYINRRVRWIRVRKKMTLAATLLEPLTESIISGLYGAWAISRLLGGNILPLFLLHMAAWISVDISTKRALETNIKGIGPPESKVTFLMAWAARECLALPIWMLAMTSSEVVWRGQKYKIIASGEAIRLGDRN

49.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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