Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins (Probable). Can phosphorylate casein on threonine residues in vitro. Involved in the regulation of flowering time through gibberellin (GA) signaling, and independently of photoperiod. Phosphorylates the DELLA protein SLR1, stabilizing SLR1 protein and sustaining SLR1 activity as repressor of GA signaling (PubMed:20400938). Required for normal development of male floral organs and grains, through modulation of GA signaling (PubMed:26202549). Targeted and repressed by the homeobox protein HAZ1 during GA signaling (PubMed:21951842). Can phosphorylate phosvitin and SLR1 in vitro. Is not required for clock function in either the presence or the absence of light signals. Involved in a genetic control pathway for photoperiodic flowering under long day (LD) conditions that includes HD1, GHD7, HD5 and HD2. Phosphorylates and activates GHD7, a major floral repressor under LD conditions. Phosphorylation of GHD7 enhances its function in the repression of EHD1, HD3A and HD3B/RFT1, and obviously delaying flowering (PubMed:23789941).

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

707 amino acids

MPELRGGVWRARLRSKKVYDVQDADPAASPVSPAPRGRTGRRGGAAAGRGNKTVAEGGGRKALKPRGKGCRAVDLCKDQPCKDLPEVIARKAVTGKAQEDLGLNKVADRAANLMMDGESGDKFAAAEDESTTTPVPERVQVGNSPEYITDRKLGKGGFGQVYVGRRVSGGGSRTGPDAQEVALKFEHRSSKGCNYGPPYEWQVYHTLNGCYGIPSVHYKGRLGDYYILVMDMLGPSLWDVWNSVGQAMSAHMVACIAVEAISILEKLHSKGFVHGDVKPENFLLGHPGSVDEKKLFLIDLGLASRWKEASSGQHVDYDQRPDVFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIRGRLPWQGYQGDNKSFLVCKKKMATSPELLCCFCPAPFKHFLEMVTNMKFDEEPNYPKLISLFDGLIEGPASRPIRIDGALKVGQKRGRMVVNLDDDEQPKKKVRLGSPATQWISVYNARRPMKQRYHYNVADSRLHQHIEKGNEDGLYISCVSSSANFWALIMDAGTGFCSQVYELSQVFLHKDWIMEQWEKNYYITAIAGATNGSSLVVMSKGTPYTQQSYKVSESFPYKWINKKWKEGFHVTSMATAGNRWGVVMSRNAGYSHQVVELDFLYPSEGIHRRWETGYRITSTAATPDQAAFILSIPKRKPMDETQETLRTSSFPSNHVKEKWSKNLYIASICYGRTVC

78.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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