Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).

Belongs to the CCR4/nocturin family.

559 amino acids

MPKEKYDPPDPRRLYTIMSAEEVASGKKSHWTELEISGRVRSLSSSLWTLTHLTALHINNNNLSRIPPEIAKLPHLVYLNLSSNKLRSLPAELGNMVTLRELLLNNNCLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQEPDGTRKLLNYMLDNLAVHPEQLPQRPWITLRERDQMMPTAVFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEITNCDADIISLQEVETEQYYTFFLETLKDRGYDGFFCPKSRAKLVSEQERKHVDGCGVFFKTEKFALVQKHTVEFNQVAMANSEGSEVMLNRVMTKDNIGVAVLLEVKKDLFATGLKPPPEKQLLLVANAHMHWDPEYSDVKLIQTMMFLSELKSIAERASGSINSSSPTSETSSIPIVLCADLNSLPDSGVVEYLSNGGVAENHKDFKELRYSDCLTNFSCNGKNGKPDGSITHSFQLKSAYEGNLMPYTNYTYDFKGVIDYIFFSKTHMSVLGVLGPLETQWLKDNNITGCPHPHIPSDHFSLLAQLEYHPPLPPLNGLHLPVHSTACESKMLTE

63.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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