Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).

In the C-terminal section; belongs to the NnrD/CARKD family.

561 amino acids

MLSRISERCTAVTGLEQVLCRHVWSAAWLRDAEPAAAASQSIDLSCLMERAGLAAYDVFASLYASQRHWLILVGSGNNGGDGYVIARHAREAGRKVTVLSMPHSKPLPTEATNAQHAWQAVGGTETMINPGTSLHLPTDVDLVVDGLLGTGISGPPREHYEEVIRHINALPVPRVAIDIPSGLNAETGEAAGACVKADHTATFICLKPGLLTGQARDYVGQLHYRSLGLEEWMIAAERMDAALCRRVALGDVYGYFSTRRSAVAHKGSCGKVVLIGGDHGFGGAILMSAEACLTIGAGLTRVLTRPEYVAPLLTRCPEVMVTAVETETSGQLEQQMVEAFEWASTLAVGPGLGTGAYGQAALSAALQQAEMHQDKTLVLDADALNLLAERLHSKEMGAAVGAGKYLPVLPNSIITPHPGEAARLLACRVADVEKDRLAAARRLAAILGGTCLLKGPGTVVHCQSSGKTAIVDAGNAGMASGGMGDVLTGLLAGLAAQRMMHDTFDTTCAAALVHGVAADMVAAEDGRGTRGIRATELIPRIPFIVNASVPSSATQQRPSGL

58.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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