Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the decarboxylation on the malonyl group attached to PigH to yield a C2 carbanion of acetyl-S-PigH. Then, the heterocyclic pyrrole group of PigG moves to the PigJ active site Cys-525 to generate a transient pyrrolyl-S-cysteinyl PigJ intermediate (acyl donor) whose pyrrolyl group is captured by the C2 carbanion of acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH.

Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

770 amino acids

MSNDKHIAPLAVVSMGCVLPGVDHFRALDTIADWETVFQSASPLAWSETSRPIQGRQMDDSGFDFKKFSIPPLFRKAVSRETRLALRAAEDALAGLVLPESLRDCCDQFCAIHLGSDAAYRNATKVGALRALAEKLQAQGCPAAEVRRRLDDYKQPLAESLGCSSHDRVGEMASSIPARIAHFAHTRGKCQTLDGADKGGLRLLQLAQDCFRYHDSQMAVLTSVQCFHHRPQAYMLLEQGVSQDACWLEGAISLVVCPLAVAHEQGWPVLTQLGDIVTTHDGSPQPEADHPAALYFAGANQVFCQIVEMVLRQHQRCEGRSFTGGRWQVNVAQTQSLTPAVDDRVAIVDYQPITGHPLDKTQFWQTLEQGEDALREHSAAHVNAEAFVRTTQQKLSTYIHRTMSFPAHSPSDVALKKPMMPAKKQRLDVTQLYALNSCHSWSEKIRQFERVAIIIASNLSLSADRLQAMRALWSGLPGSEGAIPLPELPSINHWSWYGACGIGTAQLLAQYFGISADCYAVEAACASSLAAVHDAVRALQAGRYDAVIVGGIETATLERDLVLCSAQMMLSVSRIRPFSQGADGFTPGDGGGFVMLTHHPVPRAIATIEAISGSCDSYSMTAPDPLGQALAIKKTLSLTAIDAQTVQYLEAHGTGTELGDRSEVMSLKYSYHRDKHSPLYIGSAKYNFGHCFAGAGALSLCKVLSAFEHERIPPTPVSELNVDLPLGDIPAEVPQQAIPWRLSEDGQRKAAINAFGTGGINYHLVIRQSS

83.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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