Has a broad substrate specificity. Can use synthetic substrates such as p-nitrophenyl-beta-N-acetylglucosaminide, p-nitrophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (pNP-GlcNAc), p-nitrophenyl-2-acetamido-2-deoxy-beta-D-galactopyranoside (pNP-GalNAc), 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc), and 4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc-6SO(4)) as substrates. Removes terminal GlcNAc residues from alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference.

Belongs to the glycosyl hydrolase 20 family.

580 amino acids

MLTLSKFHVILIPILFFITLLSPLFSIALPINIWPKPRFLSWPQHKAIALSPNFTILAPEHQYLSASVTRYHNLIRSENYSPLISYPVKLMKRYTLRNLVVTVTDFSLPLHHGVDESYKLSIPIGSFSAHLLAHSAWGAMRGLETFSQMIWGTSPDLCLPVGIYIQDSPLFGHRGVLLDTSRNYYGVDDIMRTIKAMSANKLNVFHWHITDSQSFPLVLPSEPSLAAKGSLGPDMVYTPEDVSKIVQYGFEHGVRVLPEIDTPGHTGSWGEAYPEIVTCANMFWWPAGKSWEERLASEPGTGQLNPLSPKTYEVVKNVIQDIVNQFPESFFHGGGDEVIPGCWKTDPAINSFLSSGGTLSQLLEKYINSTLPYIVSQNRTVVYWEDVLLDAQIKADPSVLPKEHTILQTWNNGPENTKRIVAAGYRVIVSSSEFYYLDCGHGGFLGNDSIYDQKESGGGSWCAPFKTWQSIYNYDIADGLLNEEERKLVLGGEVALWSEQADSTVLDSRLWPRASALAESLWSGNRDERGVKRCGEAVDRLNLWRYRMVKRGIGAEPIQPLWCLKNPGMCNTVHGALQDQ

65 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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