Component of the BRISC complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:26344097). Does not have activity by itself, but the catalytic subunit BRCC3/BRCC36 needs to be associated into a heterotetramer with FAM175B for minimal in vitro activity (PubMed:26344097). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1 (By similarity).

Belongs to the FAM175 family. Abro1 subfamily.

471 amino acids

MADSDLLVTISGAALSLLFFENVRSVGNQMGFLLGEALEFIVKTYTDSDNQVETVKIHINVEAIVTCPLADLLHDSTNHINKEKLKDFVRDKSKQVIGWFCFRRNTTNLTLTLKDKLLHKQFASHFSGVNGCKEDFFLTCLLNASTSETSGTHKFRHVFLRHNKRGMFEPISLKINNLGDDASRHDGSDYKPTPVRKSTRTPDSFTKLIESLNLDVARIDGLDSAMLIQKAAEHHLMSLIPKVCESDLEVAELEKQVHELKIKIATQQLAKRLKINGENCDRISKASKDNCFSEKIDSSKKNEVRIGDDACLQREHIPSCTQSVGPNNRTVCRNTAACIAKSAEKSRRAGRSNLQESGNQQQETQNFFTNSRRSIPEIATESICQEGSEISMGRGRGSGRGSHEFTPGMKKIRRTPGTSHMHSSRERSTTPPEQDFSDAECPISSPVLRSYSQVTKKTNLDKCNSMAPLDI

52.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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