Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.

Belongs to the ATG9 family.

948 amino acids

MMSSNILSRFLPPTGSPSVYETIRQHDAGSEYSDLEERAGLVIEDQQEQYSDRELEDALADAQDSEIVSPSTALLNQARSVKAPEERASPSGTRRRKSSRPRWMAQESPLGYELDDHDEDVPQSLLVEGHHEDLKPRLPPPPQSHNRSDRRRTPSPGPSSRPTEARWNERGVHQQPPPSESGHPIGRWFTGQHPGLANVDPKKKAMWRWANVEDLDNFLKDVYVYFLGNGIWSILLTRVLNLLTFAFVVGFSTFLTNCIDYPKVRRSKTLNDILVPQCTANMSGSSTFLLWLFSFFWIGKLFQYLLDIRRLKHLHDFYLYLLGVSDAEVQTISWQEVVSRLMALRDSNPSTAAAVSAKHRRFLGSQSKQRMDAHDIANRLMRKENYMIALVNKDILDLTLPIPFLKNRQLFSRTMEWNLNLCVMDYVFNEQGQLRTLFLKDTHRRALSDGLRRRFIFAGVMNIFVAPFIVVYFMMHYFFRYFNEFKKNPGQIGSRQYTPMAEWKFREFNELWHLFERRINMSYPFASRYIDQFPKDKTVQVARFVAFISGALASVLALASVIDPELFLGFEITHDRTVLFYLGIFGTVWAFARGLAPEETDVFDPEYALLELIDFTHYFPSGWKGRLHSDDVRKEFAILYQMKIVIFLEEILSMIFTPFVLWFSLPKCSDRLIDFFREFTVHVDGVGYLCSFAVFDFKKGTNVLSQAGPGRRDPGKQDLRTDYFSTKDGKMLASYYGFLDNYGTTHQATSRRPFHPPPTLPTLGSPTAGGFGALPDRPDHLQTRLGPTPGAPFGPQSMIGTSKPRQMGGFDHRSPAPSILLDPHHQPSTTGFRAAARIAPQQHQRSRLGRSHHPSTDPIDDEEEPLSQDGHDSTTRQSGARTGTSSAGAGTSDSNLGDSWRMNPLSNDEDEGDEGENIDAIAGGGGVLGLIQQFQKANTEGRRTNVGI

107.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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