Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.

336 amino acids

MGNCLHQAELSPSTENSSQLNLEDLWNFSYNGNDSFPEIDYDASLAAAAPCHSCSLLNDSSLPFFILASDLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPILAPGLGNTHSSALCSLGYCVWYGSAFAQALLLGCHASLGPKLGAGQVPGLTLGLPVGLWGATALLTLPITLASGASDGLCTPIYSTELEALQATHAVACFAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWVWFIFWWPHGLVLGLDFLVGSKLSLLPTCLAQQVLDLLLNLAEALAIVHCVATPLLLALFCHQTTRTLLPSLPLPERWSSPVDTLGSKS

35.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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