Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group.

Belongs to the archaeosine synthase type 1 family.

585 amino acids

MTDYFEVHARDGAARIGELRLSDSVTTPAVVDDVLADAGSLWAAERELPDGSDDVLTVLPHRSLPAGSADEVRESFSVAYPDVDFPSAAVVTADTADDFGADAYVLSDAQGFVGHARAFRDNVIEAKENLPADTALVLSGVATPRNVSLLVYAGVDLVDEKLARARGLEGFYLTSDGEYFLEDLDELPCACEACRKPASEFTRADAADHNANALRAELARVRRRVRDGRLRDYVEGQARHDQWLTALFRRFDQQYSFMEQRVPVIRDSELTAASEESIDRVEIQRFADRVTKRYRNRFDNPLVLLPCSAKKPYSESQSHRQFQEAVQYRAHMVSMTSPIGVVPQELELTYPAQHYDSVVTGDWSEDEKSFVAEVLRRYLERNDYPRIIAHLPPGAYTDIVERVADDLDLDVEFTVSEHPTTTESIGNLMRTLDGEPKFTREEREHNVVKALADYQLGPDAGDALFSDVALEMTSRYPKLQVWNDAGVQLATMVPQYGVLSFTLEGAKVWRDSDAPTKTVEIDGFVPHGSVLAPGVVDADEDIRPGDEVVVEGPKAFAIGRAEMGGRELVESTRGIGVEIRHVEER

65 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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