Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA.

Belongs to the HpcH/HpaI aldolase family.

435 amino acids

MSVTRHYDREFVRTFFTSPTAVDGEEDSAKMLRSAGQLRGLQAPDVWVPDNEDATAPNMRAEGVENIIDVVANQGAEFPGEIHPRVVWHRESPATRYKGFQQMLEITDPENGAVEHIDGFVIPEVGDIDDWKKADEFFTIIEHEHGLEEGSLSMSVIVESGEAELAMGDLREEMGKPSNNLERMFLLVDGEVDYTKDMRAMTPTGELPPWPELRHNTSRGASAAGLIAVDGPYDDIRDVEGYRERMKDNRAKGMTGIWSLTPGQVVEANTAPLPPKTGSWLLEAGGQEVELEAQDGKQVYDGDDLSLEEVSDGGYVLQAGGDRLELDEDELTEELLDRTAYIPSMTDIVDSMEEFEAAKEAGKGAIAMTQAATLVINGVEVDISKDRMWDEATYQAAQTPITLFQDVYEHRPDQHEELAEMYGADIVERATAVGN

48.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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