Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity).

332 amino acids

MVPREVPESSLTSLKTKDVARRRHKRRSRQHQRFMARKALLQEQESLSMVPGPGLCPLPSPTQTPAGTEASGNRKQRTKARSGSKGLCSKRPVPREAPSSGPSKYVAIDCEMVGTGPQGRVSELARCSVVSYSGDVLYDKYIRPEMPIVDYRTRWSGITRQHMHKAIPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPGSQIRDTTYVPNLLSQPSSLTRARVSLKDLALNLLHKKIQVGHHGHSSVEDAMTAMELYQLVEVQWEQQVASTAKAHPEDRGPDSSTDVEQYMDDQYWPEDLAQSTRGDTREAQDRQEGEEGQGARSAPP

37.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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