Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.

642 amino acids

MHQVVTVKAEKVPMGKRLRRCKQEAENQQKVEEVAEKLEKEHEGLIEFHKSYHELFQFFCNNTTIHGAIRLVCSKRNKMKTAFWSVLFFLTFGLMYWQFGILYREYFSFPVNLNLNLNSDKLTFPAVTLCTLNPYRYSAVRKELDELDRITHQTLMDLYNYSMSQVQSNGAAQSSQKRSQRSLSHHVQRHPLRRRKRNEPVSLKGNSPPVDKSDWKIGFILCNETNEDCFHQTYSSGVDAVREWYSFHYINILARMPDTKALDESNFESFIYACRFNEVTCDKANYTHFHHPLYGNCYTFNDRNNSLWTSSLPGINNGLSLLVRTEQNDYIPLLSTVTGARVMVHEQNEPAFMDDGGFNVRPGIETSISMRKETTMLLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQIHMVKRCGCAYYFYPLPPGAEYCDYTKHIAWGYCYYKLQVEFKSNILGCFSKCRKPCEVTKYQLSAGYSHWPSAVSENWVFHILSQQNKYNITSKRNGVAKVNIFFEEWKYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVVELAELILDFIAITIILSFKRFRSRQVPAPSVPPPGAHDNTAFQSEPADPSAPHRFTVEAVVTTLPSYNSLEPCRRDGEAVIGLE

73.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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