Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.

Belongs to the alkB family.

286 amino acids

MEDKRRRARVQGAWAGPAKSQATAQPAPTAENNLQQRPGKAWMNKEQHLSDRQFVFKEPQEGVRRAPEPRVIEKEGVYEISMSPTGISRVCLCPGFVDLKEADSVFEQLCRDVPWKQRTGIRDDVTYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLLMLKNQIEENTGHSFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRMFEMRKKPPPEDNGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRINLTFRTVYPDPRGAHW

33.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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