RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs.

Belongs to the fto family.

501 amino acids

MKKRGVLCEEEKEVKKRKLLEQIGDGHLPYLSSKDDTFYDLWGSCYSKLTLLQAKHVPVDLHHTVQNAFLSLLRNGCLFQDLVRLKGKDIITPVSRILIGRPGYTYKYLNTRLFAVPWINDELNTQYSTRNLLETYKAFSDLNDFLYSQTVNELQKLGKIHKDNFFQHSEYKEQIKSDQRPSTSNYENVKLHSMESFNVTLINYMDPQNMSFLKEEPYFGMGKMAVSWHHDENLVEQSTVAVYNYSYQESSNDVNGEDEDPTRWHVGLKIAWDIETPGLLMPLSSGDCYLMLDDLNKTHQHCVIAGCQPRFSSTHRVAESSTGTLQYIKSQCNSALQNLHMNPDTGAADLKNLEPNVLGQTEEIHNEVEFEWLRQFWFQGKRYNKCTTFWKEAMTELEIHWKQMETMTSLVLKAIENENLTVDEKCNILKNILPPLVERQDLRHDWRERCRSKLAKMLPPDQVPCFYPYWNDDNKTMPLPFDLHNIISALQKTLEENELKL

58.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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