Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery. The interaction with PDE4DIP is isoform-specific.

single

1087 amino acids

REKLEVQCQAEKVRDDLQKQVKALEIDVEEQVCRFIELEQEKNAELMDLRQQNQALEKQLEKMRKMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKLVPRFQPISEHQTREVEQLTNHLKEKTDKCSELLLSKEQLQRDVQERNEEIEKLECRVRELEQALLSVQTLSKRWRTRNSFGAVEPKAELCLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDEMEKLGFAIKESDAVSPQDQQVLFGKFAQIIHEKEVEIDRLNEQIIKLQQQLKITTDNKVIEEKNELIRDLEAQIECLMSDQERVRKNREEEIEQLNEVIEKLQQELANIDQKTSVDPSSLSEEADSLKHQLDKVIAEKLALEHQVETTNEEMAVTKNVLKETNFKMNQLTQELCSLKREREKMERIQSVPEKSVNMSVGDLSKDKPEMDLIPTEDALAQLETQTQLRSSEESSKVSLSSLETKLLQLESTVSTKDLELTQCYKQIQDMREQGRSETEMLQTKIVSLQKVLEEKVAAALVSQVQLEAVQEYVKLCADKPAVSSDPARTEVPGLSQLAGNTMESDVSALTWRISELESQLVEMHSSLISEKEQVEIAEKNALEKEKKLQELQKLVQDSETKQRERERQSRLHGDLGVLESTTSEESGVFGELEALRAESAAPKGELANYKELAEKLQEELLVKETNMASLPKELSHVRDQLTEAEDKLSHFSEKEDKTEVQEHGTICILEPCPGQIGESFASQTEGAVQVNSHTQTPQIPVRSVGIQTHSQSDSSPEEVAEIISRFTEKIEQMRELHAAEILDMESRHISETETLKREHCIAVQLLTEECASLKSLIQGLRMPEGSSVPELTHSNAYQTREVGSSDSGSDWGQGIYLTQSQGFDTASEARGEEGETSTDSFPKKIKGLLRAVHNEGMQVLSLTEGPCGDGEDYPGHQLSESWLEERRAYLSTISSLKDFITKMQVQREVEVYDSSQSHENISDWRGELLLALQQVFLRERSVLLAAFKTELTALGTRDAAGLLNCLEQRIPRTEY

124.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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