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Protein expression services for AKAP8 | A-kinase anchor protein 8

Description
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).
Family
Belongs to the AKAP95 family.
Species
Canis lupus familiaris
Length
698 amino acids
Sequence
MEQGYGGYGAWSAGPTNTQGAYGTGVASWQGYENYNYYGAQNTSVTTGASYSYGPASWETTKASDSLGAGGPAVHMASYGPEPCTDNSDSLIAKINQRLDMMSKEGGRGGSSGGGEGMQDRESSFRFQSYESYDSRSCLPEHHPYRPSYSYDYDFDPMPDRNGGFSSQYGDCRDPARERGSLDGFMRGRGQGQGQGRFQDRSNPSTFMRSDPFMPPSASSEPLSAPWPELNYVGGRGLGGPSPSRPPPSLFSQSMAPDFGVMGMQGAGGYDNSVPYGCGRSQTRMRDRPRRRGFDRCGPDGMGRKRKQLQIYDEPDAKLARADSEGDFSENDDGAADFRSGDEEFRGEDEFFDPGRQRGEKDDEDDEVKKRREKQRRRDRMRDRAADRIQFACSVCKFRSFEDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIVNRNKKIEKRRQELMEKESTKPKPDPFKGIGQEHFFKKIEAAHCLACDMLIPAQHQLLQRHLHSVDHNHNRRLAAEQFKKTSLHVARSVLNNRHIVKMLEKYLKGEDPFTSEAVDPEIEGDDTLGGEKEETPEEVAAEVLAEVITAAVRAVDGEGAPAPEGSDTPPEGQGPVDTAEATHSPHSEQLVEVETPCGAAPEKGDANAEAGGETTEAAGEEQEVVAKTDGAVDGTVRGAAPAPPVTETKAEQTEAEPKDVTPTE
Mass
76.8 kDa
Simulated SDS-PAGE
Western blot of AKAP8 recombinant protein(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make AKAP8 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

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