Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

822 amino acids

MGGRVFLAFCVWLTLLGAETQDSRDCARWCPENSSCVNATACRCNPGFSSSSEIFTSPTEICDDINECVPPSKVSCGKSSDCRNTEGSYDCVCNPGYELVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSFTCQCLPGFKFKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTICEDVDECSSGLHQCDNSTVCFNTVGSYTCRCRPGWEPKHGIPNNQKDTVCKDMNFPTWTLPPGVHSQTLSQFFNKVQDLDRDFKTSSAKVTIQSILKELDELLEAPGDLETLPRFQQHCVATHLLDGLEDVLRGLSKNPSIGLLNFSYPAGTEFSLEVQKQVDRNVTLRQNQATMQLHWNLAQKSGDPGPSVVGLVSVPGMGKLLAEAPLVSEPENQVVRNETHQGLLPILLSDVISAFLSNNDTQNLSSPVTFIFSHRSVIPRRKVLCVFWEHGQNGCGHWATTGCSTMDTRDTSTICRCTHLSSFAVLMAPYDVQEEDPVLTVITYMGLSLSLLCLLLAALTFLLCKAIQNISTSLHLQLSLCLLLAHLLFLVAIDRTEHEVLCAIIASALHYLYLAAFTWMLLEALYLFLTARNLMVVNYSSINRFTKKLMFPVAYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLALLLVTLWILKNRLSSLNNEVSTLQNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYRKWSKGFRKLRTESEMHTLSSSAKRDTPKPSTPGLLGLQS

90.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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