Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

Belongs to the adenylosuccinate synthetase family.

448 amino acids

MSTTIAVNGNHYQQLHQGRTSMYKSKVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVNTHLRLFPSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICITKLDILDTLPEIKVGVSYKRSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLESQLSVPVRWVGVGKGRESIINVH

49.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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