Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span.

Belongs to the adenylosuccinate synthetase family.

447 amino acids

MSASATNGTHYEQLHQGRTKMYKSKVDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSINVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAELGNIEVEYAVLPGWQTSTEEVRNFKELPENAQSYVRLLESELSVPVRWVGVGKGRESIINVH

48.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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