Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

Belongs to the adenylosuccinate synthetase family.

424 amino acids

MGVSIVLGSQWGDEGKGKITDMLAQQATLCCRAAGGHNAGHTIVHGNKTYDFHILPSGLISPSCINLIGAGTVVHVPSFFKELASLEEKGLEGASKRIFISDRAHVCLQLHSVVDGLEEAKLGGRKVGTTGKGIGPCYSDKASRRGIRVGEILDEAVFERKLRSLDAGYRARFGDLEYNVEEELAQFKEYRKLLGPYIVDQLAFLQKYKDSPNTLVEGANALMLDLDHGTYPYVTSSSTGLGGAMQALSLNPTSIKSVIGVVKAYTTRVGSGPFPSEQFNADGDKLQSVGREFGVTTGRRRRCGWLDLVVCRYSQAINHYTALNLTKLDVLDDFDEIKVGVAYILPDGTRTENTIPADAEVLEKVKVEYVTLPGWKSNTMGVKKYEDLPDNARAYIEYIERELGGVPVKWIGTGPARDDMIARE

46.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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